组织蛋白酶V的研究进展

Research Progress of Cathepsin V

组织蛋白酶V (cathepsin V,CTSV)作为半胱氨酸组织蛋白酶家族的一员,在人胸腺、睾丸、乳腺中特异性高表达。CTSV在酸性环境下保持最佳生物活性,参与机体皮肤生长、免疫功能、神经递质产生等多个系统的生物学过程,并与重症肌无力、1型糖尿病、动脉粥样硬化等疾病发病机制密切相关。通过对CTSV的深入了解和研究,可以为今后开发抗肿瘤药物(如乳腺癌和大肠癌等)、治疗免疫疾病及动脉粥样硬化等疾病提供新思路。

As a member of the cysteine cathepsins family, cathepsin V is highly expressed in human thymus, testis and breast. Cathepsin V maintains the optimal biological activity in acidic environment. Cathepsin V participates in multiple biological processes such as skin growth, immune regulation and neurotransmitters production, and is closely related to the pathogenesis of myasthenia gravis, type 1 diabetes mellitus and atherosclerosis. Through in-depth understanding and research of cathepsin V, it can provide new ideas for the development of anti-tumor drugs, such as breast cancer and colorectal cancer, and the treatment of immune diseases, atherosclerosis and other diseases.