噻托溴铵联合孟鲁司特治疗哮喘-慢性阻塞性肺疾病重叠疗效观察

Efficacy of tiotropium bromide combined with montelukast in the treatment of asthma complicated with chronic obstructive pulmonary disease

目的:探讨噻托溴铵联合孟鲁司特钠治疗哮喘-慢性阻塞性肺疾病重叠的临床价值。方法:收治哮喘-慢性阻塞性肺疾病重叠患者28例,随机分成A组和B组。A组采用常规药物及孟鲁司特治疗,B组在常规治疗基础上加用噻托溴铵、孟鲁司特治疗,比较两组治疗效果。结果:治疗2周后,FEV_1和PEF有明显升高,B组显著高于A组(P<0.05)。呼吸困难评分结果显示B组显著优于A组(P<0.05)。结论:噻托溴铵联合孟鲁司特钠治疗哮喘-慢性阻塞性肺疾病重叠的临床价值较高。

Objective：To explore the clinical value of tiotropium bromide combined with montelukast in the treatment of asthma complicated with chronic obstructive pulmonary disease.Methods：28 patients with asthma complicated with chronic obstructive pulmonary disease were selected and they were randomly divided into the A group and the B group.The A group was treated with routine treatment and montelukast,the B group added with tiotropium bromide combined with montelukas on the basis of routine treatment,we compared the therapeutic effects of the two groups.Results：After treatment for 2 weeks,the levels of FEV1% and PEF% were increased significantly,and the B group was significantly higher than that of the A group（P〈0.05）.The dyspnea score showed that the B group was significantly better than the A group（P〈0.05）.Conclusion：The clinical value of tiotropium bromide combined with montelukast in the treatment of asthma complicated with chronic obstructive pulmonary disease was high.