HBP表达水平对脓毒症的预警评估作用研究进展

HBP Expression Level and Sepsis Prediction

肝素结合蛋白(heparin-binding protein,HBP)是一种多功能蛋白,具有杀菌功能和趋化特性,在脓毒症的发生、发展中起重要作用。机体感染后,HBP通过各种方式释放,作用于靶细胞,分泌炎症介质,引起炎症反应。HBP作为一种颗粒释放蛋白,与细菌感染有紧密的关系,作为临床新型炎症标志物,HBP存在较宽的窗口期,具有早期、特异、敏感的特性,优于传统的炎症标志物,且对脓毒症的早期预警、预测评估及疗效观察具有特异性的临床价值。

Heparin-binding protein（HBP）is a multifunctional protein with broad antibacterial and chemotactic activity,which plays crucial role in the occurrence and development of sepsis.HBP is released immediately upon infection and then functions on the target cell,which acts as an amplifier of inflammatory responses.As a kind of granular release protein,HBP has been shown to correlate with bacterial infection.Recently,HBP was described as a useful biomarker with extensive window period and the characteristics of being early,specific and sensitive,which was superior to traditional inflammatory markers.Consequently,HBP has the potential clinical application value for sepsis prediction and treatment.