NICU 9例近平滑假丝酵母菌脓毒血症的临床分析

Clinical analysis of 9 cases of the Candida parapsilokis pyemia in NICU

目的探讨分析新生儿重症监护室内近平滑假丝酵母菌脓毒血症的临床特点,为临床诊断与治疗提供良好的理论依据。方法选取2017年1月1日至2018年1月1日在我院新生儿科就诊的9例近平滑假丝酵母菌脓毒血症患者,总结其临床表现,对其易感因素进行探讨和分析。结果新生儿近平滑假丝酵母菌脓毒血症没有典型临床表现,常伴随(1-3)-β-D-葡聚糖升高、血小板减少等特点。9例早产儿患者,在接受治疗后7例治愈出院,1例自动出院,1例合并坏死性小肠结肠炎术后放弃治疗死亡。结论早产儿、低出生体重儿、留置PICC及长期应用广谱抗生素为其主要高危因素,愈早治疗效果和预后愈好。

Objective To analyze the clinical characteristics of neonatal Candida parapsilokis pyemia in neonatal intensive care unit（NICU）,so as to provide a good theoretical basis for clinical diagnosis and treatment. Methods Nine cases of neonatal Candida parapsilokis pyemia from January 1 st 2017 to January 1 st 2018 in our department were selected,the clinical manifestations and the susceptible factors were analyzed. Results Neonatal Candida parapsilokis pyemia had no typical clinical manifestations,some of which accompanied by the characteristics of（1-3）-β-D-glucan and thrombocytopenia. All of the 9 cases were preterm infants.After treatment,7 cases were cured and discharged,1 case left hospital voluntarily,and 1 case died of necrotizing enterocolitis and gave up treatment after surgery. Conclusion Preterm infants,low birth weight infants,indwelling PICC,and long-term use of broad spectrum antibiotics are the mainly risk factors,and early treatment will bring better results and prognosis.