红花籽亚麻籽复合油对小鼠血糖的干预作用

Effect of Mixture of Safflower and Flaxseed Oil on Blood Glucose in Diabetic Mice

本文探讨了红花籽亚麻籽复合油对糖尿病小鼠血糖的干预作用。使用链脲佐菌素(STZ)建立小鼠糖尿病模型,对建模成功的小鼠进行随机分组(分别为高血糖对照组、红花籽油组、亚麻籽油组、亚麻籽油提取物组、红花籽亚麻籽复合油组。每组12只,雌雄各半)。试验小鼠按分组灌胃给予受试物,持续14 d。末次给药30 min后,为小鼠灌胃给予2 g/kg葡萄糖,分别于10、30、60、90、120 min处检测小鼠血糖,得出小鼠血糖曲线下面积(AUC)相对值、胰岛β细胞功能(HOMA-β)和胰岛抵抗指数(HOMA-IR)。结果表明:红花籽亚麻籽复合油组小鼠餐后30 min血糖浓度(15.73 mmol/L)与高血糖对照组(17.38 mmol/L)相比,具有显著性差异(p<0.05),GI、HOMA-β、HOMA-IR均具有一定差异,但无统计学意义(p>0.05)。因此,红花籽亚麻籽复合油可降低糖尿病小鼠的AUC,提高其胰岛素的分泌及靶细胞对胰岛素的敏感性。

The investigate the intervention of mixture of safflower and flaxseed oil on blood glucose in diabetic mice was investigated. A mouse model of diabetes was established using streptozotocin（STZ）, and the mice were randomly divided into five groups（high blood glucose control group, safflower oil group, linseed oil group, linseed oil extract group, mixture of safflower and flaxseed oil group, 12 in each group, half male and half female）. The mice were given the test samples in groups for 14 days. After 30 min of the last administration, mice were given 2 g/kg of glucose by gavage, the blood glucose was measured at 10 min, 30 min, 60 min, 90 min, and 120 min, respectively, and the relative value of area under blood glucose curve（AUC） in mice, pancreatic β-cell function（HOMA-β） and islet resistance index（HOMA-IR） were obtained. The results showed： There was a significant difference（P〈0.05） in blood glucose concentration 30 min after meal in mice of mixture of safflower and flaxseed oil group（15.73 mmol/L） and high blood glucose control group（17.38 mmol/L）. Therefore, compound oil of safflower seed and flaxseed could reduce AUC and increase insulin secretion and sensitivity of target cells to insulin in diabetic mice.