双酚A人群暴露情况和健康风险研究进展

Human exposure to bisphenol A and its health risks: a review

人类通过多种途径暴露于双酚A(BPA),膳食暴露是普通人群暴露途径之一。人群膳食暴露量评估资料表明,BPA的膳食暴露量远低于美国推荐的可耐受每日摄入量(50μg/kg·bw/d)。BPA进入人体后表现为弱的雌激素作用,干扰人体内分泌系统,对人体健康风险表现在影响女性激素水平、胎儿的生长发育和男性生殖系统功能,与儿童肥胖、复发性流产、多囊卵巢综合征、2型糖尿病相关。研究表明,人群暴露于BPA呈现出多途径、低剂量、长期暴露的特点,该特点的暴露会对人体健康有一定影响。

Human are exposed to bisphenol A（BPA） through various ways and dietary exposure is among one of them in general populations. The data on dietary exposure assessment indicated that the levels of human exposure to BPA are much lower than the tolerable daily intake（50μg/kg·bw/d） recommended by United States. Studies have revealed that BPA plays a weak estrogen-like role in human body resulting in endocrine disorder. For human health risks, BPA exposure was recognized to have impacts on levels of female sex hormone, functions of male reproductive system, and fetus growth and development and in addition to have relations with children obesity, recurrent abortion, polycystic ovary syndrome, and type2 diabetes. BPA may lead to human health effects with a long-term low level exposure via various routes among general populations.