GⅡ.17型诺如病毒流行概况及分子进化特征研究进展

Researches on prevalence and molecular evolution of norovirus GⅡ.17: an overview

GⅡ.P17_GⅡ.17诺如病毒株是2014—2015年亚洲出现的变异株,其导致的疾病,在发病规模、感染人数、发病程度等方面,均盛于诺如病毒流行株GⅡ.4。虽是新毒株,但近年来,利用自组装病毒样颗粒蛋白(VLPs)系统对诺如病毒GⅡ.P17_GⅡ.17的研究比较多,包括病毒衣壳蛋白结构、受体结构、进化机制等方面。这些研究为诺如病毒引起的急性腹泻等相关疾病的预防控制和疫苗研制奠定了良好的理论基础。

The norovirus GⅡ.P17_GⅡ.17 is a new variant strain emerging in Asia from 2014 through 2015, which was contributed to the epidemics involving much more sufferers, larger scales, and stronger severity than norovirus GⅡ.4. In recent years, there have been many researches on structure of capsid protein and receptor and evolution mechanism of norovirus GⅡ.P17_GⅡ.17 with the application of self-assembled virus like particles（VLPs）. These researches provide a theoretical basis for the prevention and control of relevant diseases, such as acute diarrhea, and the development of vaccine.