尼尔雌醇在绝经后妇女取出宫内节育器前的应用

Application of nilestriol in postmenopausal women before removing intrauterine device

宫内节育器是一种长期、高效、安全、简便的避孕方法,且可逆。绝经后女性雌激素水平急剧下降,导致阴道、宫颈和子宫体萎缩,宫颈变得狭窄、缺乏弹性,导致取器困难。尼尔雌醇为长效口服型雌三醇衍生物,有较强雌激素活性,能选择性作用于阴道及宫颈,而对子宫内膜作用很小。雌激素可以促进阴道黏膜上皮及宫颈组织增生、黏膜分泌物增多、弹性增加,从而使萎缩的阴道、宫颈变软,易于扩张。绝经后妇女取器术前口服尼尔雌醇可软化宫颈,提高取器成功率。

Intrauterine device is a long-term, efficient, safe, simple and reversible method of contraception.The postmenopausal women with a sharp decline in estrogen levels leading to the vagina, cervix and uterus atrophy, cervical stenosis and lack of elasticity, increase the difficulty of the intrauterine contraception removal.Nilestriol is a long-acting orally administered estriol derivative with strong estrogen activity that selectively acts on the vagina and cervix with little effect on the endometrium. Estrogen can make vagina mucosa and cervical hyperplasia, mucous secretion and elasticity increased, thus the vagina and cervix become soft, easy to expand.Postmenopausal women take orally nilestriol before operation can soften the cervix and improve the success rate of the removing intrauterine device.