红细胞存储损伤影响因素研究进展

Progress on Influencing Factors of Red Blood Cell Storage Lesion

血液在存储过程中由于受多种因素的影响,其形态、功能和生物化学等方面均发生不同程度的变化,且随着存储时间的延长变化更加显著,这些变化统称为"存储损伤"。红细胞(RBCs)存储损伤是多层面的生物现象,表现为大量生化和形态学改变的积累。RBCs存储损伤是多方面因素作用的结果,献血者个体差异、RBCs制备及存储过程中的诸多因素均会影响存储RBCs的质量,导致相同存储时间RBCs的保存质量有所不同,进而影响RBCs临床输注效果。论文结合国内外存储损伤的研究现状,对影响存储损伤的因素进行了系统综述,以期为抗存储损伤的研究及输血安全提供理论依据。

Due to many factors, storage blood changes in different degrees such as morphology, function, bio- chemistry and so on, the changes become more significant with the prolongation of storage time. These changes are ＂storage damage＂.Red blood cells （RBCs） storage lesion is a multifaceted biological phenome- non,characterized by a large number of biochemical and morphological changes accumulated.RBCs storage lesion is the result of multiple factors, both of the individual differences of blood donors and the preparation process of RBCs can affect the quality of stored RBCs, so in the same storage time, the quality of stored RBCs is different, and the clinical transfusion effect is also varied. This article, combined the progress of RBCs storage lesion at home and abroad, systematically reviewed the factors affecting storage damage in order to provide a theoretical basis for the study of anti-storage damage and blood transfusion safety.