胰腺癌患者血清中PRDM14和S100P水平及临床意义

Serum levels of PRDM14 and S100P of pancreatic cancer case and investigation of the clinical value

目的:检测胰腺癌患者血清正性调节区锌指蛋白-14(PRDM14)和S100P水平变化,探讨其临床价值。方法:选取本院收治的胰腺癌患者52例(胰腺癌组),另纳入在本院体检且结果无异常者50例(对照组)。检测两组血清PRDM14和S100P水平。分析胰腺癌患者血清PRDM14和S100P水平与临床病理特征的关系。治疗后随访6个月,比较胰腺癌组中死亡组与存活组患者入院时血清PRDM14和S100P水平。结果:胰腺癌患者血清PRDM14和S100P水平高于对照组(P<0.01)。胰腺癌患者血清PRDM14和S100P水平在年龄、性别、肿瘤部位方面无统计学差异(P>0.05),在临床分期、分化程度方面有统计学差异(P<0.05)。6个月随访结果:29例死亡,23例存活,死亡组患者入院时血清PRDM14和S100P水平高于存活组(P<0.05)。结论:胰腺癌患者血清PRDM14和S100P水平明显提高,与其临床病理参数与恶性程度存在一定关系,可能是临床评估胰腺癌预后的有效指标。