RNA结合基序蛋白25在肺腺癌组织中的表达及与预后的关系

Expression of RNA binding motif 25 in lung adenocarcinoma tissue and its relationship with prognosis

目的探讨肺腺癌组织中RNA结合基序蛋白25(RBM25)的表达以及与临床病理参数、患者预后之间的关系。方法采用免疫组织化学法检测75例肺腺癌组织和相应癌旁组织中RBM25、Ki-67和B细胞淋巴瘤2(Bcl-2)的表达水平,并分析肺腺癌组织中的RBM25表达与患者临床病理参数、患者预后的关系。结果在75例肺腺癌组织中RBM25表达的阳性率为13.3%,明显低于相应癌旁组织的93.3%(P<0.05);RBM25表达阳性率与肿瘤大小、TNM分期相关(P<0.05),而与性别、年龄、病理分级和淋巴结转移无相关性(P>0.05)。生存分析显示,RBM25阳性患者的累计生存率为60.00%,明显高于RBM25阴性患者的26.15%(P<0.05)。肺腺癌组织中RBM25表达与Ki-67和Bcl-2均呈负相关关系(r=-0.259、-0.338,P<0.05)。结论 RBM25在肺腺癌组织中低表达,而其低表达可能与肿瘤增殖及患者的不良预后相关。

Objective To investigate the relationship between RNA binding motif 25（RBM25）expression in lung adenocarcinoma tissue with clinicopathological parameters and prognosis in the patients with lung adenocarcinoma.Methods The expression levels of RBM25,Ki-67 and Bcl-2 in 75 cases of lung adenocarcinoma tissues and corresponding paracancerous tissues were detected by adopting the immunohistochemical method.The relationship between RBM25 expression in lung adenocarcinoma tissues with clinicopathological parameters and prognosis of the patients was analyzed.Results The positive rates of RBM25 expression in lung adenocarcinoma tissues of 75 cases of lung adenocarcinoma was 13.3%,which was significantly lower than 93.3%in the corresponding paracancerous tissues（P〈0.05）.The RBM25 expression positive rate was correlated with the tumor size and TNM stage（P〈0.05）,while had no correlation with the sex,age,pathological stage and lymph node metastasis（P〈0.05）.The survival analysis showed that the cumulated survival rate of the patients with positive RBM25 was 60.00%,which was significantly higher than 26.15%in the patients with RBM25 negative（P〈0.05）.The expression of RBM25 in the lung adenocarcinoma tissues was negatively correlated with Ki-67 and Bcl-2（P〈0.05）.Conclusion RBM25 is lowly expressed in lung adenocarcinoma tissues,and its low expression may be associated with tumor proliferation and poor prognosis of the patients.