不同病因、症状、病程肝硬化患者血小板参数比较

Comparison of platelet parameters among cirrhotic patients with different etiological factors,symptoms and disease courses

目的探讨由不同病因、不同症状和病程的肝硬化患者血小板参数是否有差异。方法选择江苏省南通大学附属海安医院2016年4月至2017年1月确诊的肝硬化患者85例纳入研究组,另取同期健康体检者85例纳入对照组,由同一检验人员对所有研究对象进行血小板参数检测。结果研究组患者的血小板计数(PLT)和血小板比容(PCT)水平均明显低于对照组(P<0.05),平均血小板分布宽度(PDW)和平均血小板体积(MPV)均明显高于对照组(P<0.05);研究组中,乙型肝炎病毒引起的肝硬化患者MPV明显低于非病毒因素引起的患者(P<0.05);代偿期患者PLT、PCT高于失代偿期患者(P<0.05);消化道出血患者PLT和PCT明显低于无消化道出血患者(P<0.05),MPV高于无消化道出血患者(P<0.05)。结论不同病因、症状、病程的肝硬化患者血小板参数有明显不同,可通过监测血小板参数了解肝硬化患者的肝功能状况,为临床进一步诊断和治疗提供参考依据,对及早预判肝硬化出血有重要的意义。

Objective To research whether the platelet（PLT）parameters having difference in the cirrhotic patients with different symptoms and courses caused by different etiological factors.Methods Eighty-five patients with definitely diagnosed liver cirrhosis in the affiliated Haian hospital of Nantang University from April2016 to January 2017 were selected as the research group and contemporaneous 85 subjects undergoing healthy physical examination served as the control group.The PLT parameters in all research subjects were detected by the same laboratory technician.Results The PLT count and thrombocytocrit（PCT）in the research group were lower than those in the control group（P〈0.05）,the mean platelet distribution width（PDW）and mean platelet volume（MPV）were significantly higher than those in the control group（P〈0.05）;MPV of cirrhotic patients caused by hepatitis B in the research group was significantly lower than that of the patients with nonviral factors（P〈0.05）;PLT and PCT in th patients with compensated stage was higher than that in the patients with decompensated stage（P〈0.05）;PLT and PCT in the patients with digestive tract hemorrhage was significantly lower than that in the patients without digestave tract hemorrhage（P〈0.05）,while MPV was higher than that in the patients without digestive tract hemorrhage（P〈0.05）.Conclusion The PLT parameters are significantly different from the patients with different etiological factors,symptoms and disease courses,and monitoring the PLT parameters can understand the liver function status in cirrhotic patients to provide the reference basis for further diagnosis and treatment in clinic,and has an important significance for in time predicting liver cirrhosis hemorrhage.