硫酸镁联合硝苯地平治疗妊娠期高血压综合征的临床疗效观察

Clinical observation of magnesium sulfate combined with nifedipine in the treatment of pregnancy induced hypertension

目的:探讨硫酸镁联合硝苯地平治疗妊娠高血压综合征(简称妊高征)的效果及作用。方法:选取治疗并确诊为妊高征的孕妇120例,随机分为对照组60例和研究组60例,观察统计治疗前后血压、血黏度、尿蛋白、S/D和RI的变化和治疗有效率。结果:研究组的收缩压和舒张压的下降水平均优于对照组,且具有显著性差异,有统计学意义(P <0. 05)。研究组患者的血黏度、尿蛋白以及S/D和RI下降幅度大于对照组,差异有统计学意义(P <0. 05)。研究组治疗有效率为96. 97%显著高于对照组(85%),差异有统计学意义(P <0. 05)。结论:硫酸镁联合硝苯地平能够有效降低患者血压,能够有效治疗妊高征,较单独给予硫酸镁有明显优势,值得推广。

Objective To investigate the effect and effect of magnesiunl sulfate combined with nifedipine in the treatment of pregnancy induced hypertension. Method 120 cases of pregnant women who were treated and diagnosed with pregnancy - in- duced hypertension were randomly divided into control group （n = 60） and study group （n = 60）. The blood pressure, blood vis- cosity- and urine were measured before and after statistical treatment. Protein, S / D and RI changes and treatment efficien- cy. Results The systolic and diastolic blood pressure of the study group were better than those of the control group, and there was significant difference（P 〈 0. 05）. The blood viscosity-, urinary- protein, S/D and RI of the study group were significantly higher than those of the control group （P 〈0. 05）. The effective rate was 96. 97% in the study group which was higher than 85% in the control group （ P 〈 0. 05 ）. Conclusion Magnesium sulfate combined with nifedipine can effectively reduce the blood pressure of patients, can effectively treat pregnancy induced hypertension, compared with magnesium alone has obvious advantages, it is worth promoting.