支气管肺炎患儿机体免疫功能临床特点分析

Clinical characteristics of immune function in children with bronchopneumonia

目的:对支气管肺炎患儿免疫球蛋白、补体(C_3、C_4)指标和T淋巴细胞亚群进行检测,分析探讨支气管肺炎患儿免疫功能变化的临床特点。方法:将60例支气管肺炎患儿作为研究组,将60例同期门诊体检健康儿童作为对照组。应用免疫速率散射比浊法和流式细胞仪对两组免疫球蛋白、T淋巴细胞亚群以及补体C_3、C_4实验室指标进行检测,并进行对比分析。结果:研究组患儿CD_4^+/CD_8^+比值、CD_3^+、CD_4^+T淋巴细胞均显著低于对照组,差异有统计学意义(P<0.05),而CD_8^+T淋巴细胞水平则显著高于对照组(P<0.05)。研究组补体C_3及Ig M、Ig A、Ig G指标水平均显著低于对照组(P<0.05)。两组补体C_4指标水平比较,差异无统计学意义(P>0.05)。结论:儿童发生支气管肺炎时机体免疫功能会出现明显紊乱,对其免疫功能进行积极检测对后续诊疗具有重要的临床意义。

Objective To investigate the immunoglobulin, T lymphocyte subsets and the laboratory- indexes of complentent C3 and C4 in children with bronehopneumonia, and to explore the clinical features of the immune function of children with broncho- pneumonia. Method 60 children with bronehopneumonia were selected as the study group. 60 cases of healthy children in the same period were taken as the control group. The immunoglobulin,T lymphocyte subsets and C3 and C4 laboratory- indexes of the two groups of children were examined by the immunization rate turbidimetry- and flow eytometry. Test, and carry- on the contrast a- nalysis. Results The CD4/CD8＋ ratio, CD3＋ and CD4 T lymphoeytes in the study group were significantly lower than those in the control group （ P 〈 0. 05 ）, but the level of CDs＋ T lymphocyte was significantly higher than that of the control group （ P 〈 0. 05 ） . The level of complement C3 and IgM, IgA, IgG in the study group were significantly lower than that of the control group （ P 〈 0. 05 ） ; the two groups of children eomplements were significantly lower than those in the control group （ P 〈 0. 05 ）. There was no significant difference in C4 index level （P 〉 0. 05 ）. Conclusion In children with trachea pneumonia, the imnmne function of the body has obvious disorder, and the positive detection of its immune function is of important clinical significance for the follow - up diagnosis and treatment.