凉血散瘀温经通脉方治疗糖尿病周围神经病变临床研究

Clinical study on treatment of diabetic peripheral neuropathy with Liang Xue San Yu Jing Tong Mai Fang

目的研究中药凉血散瘀、温经通脉方治疗糖尿病周围神经病变的临床效果。方法选择本院收治的,获得临床诊断的糖尿病周围神经病变患者38例作为研究对象,将其按照随机数字表法分成对照组和治疗组,每组19例。对照组采用常规西药进行治疗;治疗组在常规西药基础上,加用凉血散瘀、温经通脉方进行治疗。对比两组患者血液流变学和血脂水平相关指标在治疗前后的改善幅度、糖尿病周围神经病变药物治疗总有效率、对药物治疗方案和达到效果的满意度、糖尿病周围神经病变症状消失时间和用药治疗总时间、药物不良反应发生情况。结果治疗组患者血液流变学和血脂水平相关指标在用药治疗前后的改善幅度较对照组大,组间数据对应差异具有统计学意义(P<0.05);糖尿病周围神经病变的药物治疗总有效率为94.7%,对临床用药方案和达到效果的满意度为94.7%,均高于对照组的68.5%和78.9%,差异具有统计学意义(P<0.05);糖尿病周围神经病变症状消失时间和用药治疗总时间短于对照组,组间差异具有统计学意义(P<0.05);仅有1例患者出现药物不良反应,少于对照组的5例(P<0.05)。结论糖尿病周围神经病变患者采用中药凉血散瘀、温经通脉方进行治疗,可以在最大程度上改善血液流变学指标,减少药物不良反应,缩短用药时间。

Objective To study the clinical effects of cooling blood and dispersing blood stasis and warming meridian Tongmai Recipe on dia- betic peripheral neuropathy. Methods 38 patients with clinical diagnosis of diabetic peripheral neuropathy were selected and divided into control group and treatment group according to the random digital table method, with 19 cases in each group. The control group was treated with convention- al western medicine, while the treatment group was treated with cooling blood stasis and Wen Jingtong pulse on the basis of conventional western medicine. The improvement of blood rheology and blood lipid level related indexes before and after treatment, the total effective rate of drug treat- ment for diabetic peripheral neuropathy, the satisfaction of the drug treatment plan and the effect, the disappearance time of diabetic peripheral neu- ropathy, the total time of medication treatment and the adverse drug reaction were compared between the two groups. Results The improvement of blood rheology and blood lipid levels in the treatment group was larger than that of the control group before and after the treatment. The corresponding difference between the groups was statistically significant （P〈0.05）; the total effective rate of the diabetic peripheral neuropathy was 94.7%, and the satisfaction of the treatment plan and the effect was 94.7%, compared with 68.5% and 78.9% of the control group, the difference was statistically significant （P〈0.05）; the time of disappearance of the symptoms of diabetic peripheral neuropathy and the total time of medication were shorter than those in the control group （P〈0.05）; only 1 cases had drug ungood reaction, and 5 cases were less than that of the control group （P〈0.05）. Conclusion The patients with diabetic peripheral neuropathy can improve the hemorrheology index, reduce the adverse drug reaction and shorten the time of drug use.