米非司酮与甲氨蝶呤保守治疗宫外孕的疗效临床观察

Clinical observation of mifepristone and methotrexate in the conservative treatment of ectopic pregnancy

目的观察米非司酮与甲氨蝶呤保守治疗宫外孕的临床疗效。方法在本院2016年8月～2017年8月期间收治的宫外孕患者中随机选取60例作为观察对象,并随机分配患者加入对照组和观察组,各30例。仅使用甲氨蝶呤治疗对照组患者,观察组患者的治疗药物则在对照组的基础上添加米非司酮。对两组患者治疗后包块、腹痛、阴道流血消失时间及β-HCG水平恢复正常所需时间做观察记录,另外还需要记录两组患者治疗后不良反应发生情况。结果两组患者经过不同的方案进行治疗后,对照组患者包块、腹痛、阴道流血消失时间及β-HCG水平恢复正常所需时间均长于观察组患者,且不良反应发生率高于观察组患者,两组数据比较差异具有统计学意义(P<0.05)。结论应用米非司酮联合甲氨蝶呤的方案保守治疗宫外孕患者疗效确切,临床治疗上具有高应用价值。

Objective To observe the clinical efficacy of mifepristone and methotrexate in the conservative treatment of ectopic pregnancy. Methods 60 cases of ectopic pregnancy admitted by our hospital from August 2016 to August 2017 were randomly selected as the observation ob- jects, and 30 cases were randomly assigned to the control group or observation group. Patients in the observation group were treated with methotrex- ate alone, and mifepristone was added on the basis of the control group. After treatment in patients with two groups of bag piece the disappearance time of vaginal bleeding, abdominal pain, and beta HCG levels back to normal time needed for observation records, you also need to record in the two groups after treatment in patients with adverse reactions occur. Results Two groups of patients after different treatment schemes, control group patients disappeared bag piece, abdominal pain, vaginal bleeding time and the time needed for beta HCG levels back to normal are longer than the observation group of patients, and the incidence of adverse reaction is higher than the observation group of patients, two groups of data are statistically significant difference （P〈0.05）. Conclusion Mifepristone combined with methotrexate is effective and effective in treating ectopic pregnancy.