慢性阻塞性肺疾病患者肺部真菌感染的病原学特点及危险因素分析

Pathogenic characteristics and risk factors of pulmonary fungal infection in patients with chronic obstructive pulmonary disease

目的探讨慢性阻塞性肺疾病(COPD)患者发生肺部真菌感染后表现出的病原学特点以及系列危险因素。方法选择山东省定陶区人民医院2015年6月～2017年9月收治的75例COPD合并肺部真菌感染患者作为实验观察组;同时间段选择75例COPD未合并肺部真菌感染患者作为实验对照组;针对两组患者病历资料加以分析,针对病原学特点以及系列危险因素加以分析。结果患者年龄超过65岁、选择类固醇激素进行治疗、对患者施以机械通气治疗、准备导管对患者进行体内留置、患有慢性基础病以及患者住院时间超过20天会导致患者出现肺部真菌感染的情况。结论对于COPD患者在预防其表现出肺部真菌感染过程中,需要对患者的原发病以及合并症进行有效治疗,合理选择激素加以干预,将对症支持治疗力度显著加强,最终使得治疗免疫力获得显著增强。

Objective To investigate the pathogenic characteristics and risk factors of pulmonary fungal infection in patients with chronic ob- structive pulmonary disease （COPD）. Methods Seventy-five COPD patients with pulmonary fungal infection admitted to the People＇ s Hospital of Dingtao District of Shandong Province from June 2015 to September 2017 were selected as the experimental observation group and 75 COPD patients without pulmonary fungal infection as the experimental control group. A series of risk factors were analyzed. Results Patients over 65 years of age, more than 3 weeks of broad-spectrum antibiotics, steroid hormones, mechanical ventilation, catheter retention, chronic underlying diseases, and hospitalization for more than 20 days could lead to pulmonary fungal infections. Situation. Conclusion In order to prevent COPD patients from showing pulmonary fungal infection, it is necessary to treat their primary diseases and complications effectively, and to intervene with hormones and antibiotics reasonably, so as to enhance the intensity of symptomatic support and treatment, and eventually to enhance the treatment immunity.