中药汤剂联合西药口服治疗痛风性关节炎预后的Meta分析

Meta-analysis of the Prognosis of Oral Traditional Chinese Medicine Decoction Combined with Western Medicine in the Treatment of Gouty Arthritis

目的从有效率及复发率对中药汤剂联合西药治疗GA进行分析,以期为中药汤剂联合西药治疗GA提供更新的、全面的循证医学证据。方法以"痛风性关节炎"或"痛风"自由组合"中西医""中药联合西药""中医""中药"为检索词在CNKI、万方、维普,以"gouty arthritis"或"gout"自由组合"chinese medicine""herb"为检索词在PubMed、Science Direct、Springer Link数据库中检索相关的随机对照试验(RCTs),2名研究者分别独立进行文献筛选、质量评价和数据提取,使用Rev Man5.3软件依据cochrane系统评价方法进行Meta分析。结果共纳入5篇RCTs文献,542例患者。Meta分析结果提示,中药汤剂联合西药口服的临床有效率优于西药对照组,复发率低于西药对照组(P<0.05)。结论口服中药汤剂联合西药在治疗痛风性关节炎方面存在一定优势,与西药治疗相比,复发率较低。

Objective To analyze the efficacy and recurrence rate of traditional Chinese medicine decoction combined with Western medicine in the treatment of GA,in order to provide updated and comprehensive evidence-based medical evidence for traditional Chinese medicine decoction combined with Western medicine treatment of GA.Methods ＂Gypsy arthritis＂or＂gout＂ free combination of＂Chinese and Western medicine＂,＂Chinese medicine combined with western medicine＂,＂Chinese medicine＂and＂herb＂as the search terms in CNKI,Wanfang,Weipu,free combination of＂gouty arthritis＂or＂gout＂＂Chinese medicine＂＂herb＂searches for relevant randomized controlled trials （RCTs）in PubMed,Science Direct,and Springer Link databases.Two authors independently perform literature screening, quality evaluation,and data extraction,using Rev ManS.3.The software performs a meta-analysis based on the cochrane systematic review method.Results A total of 5 RCTs were included and 542 patients were included.The results of meta-analysis suggest that the clinical efficacy of traditional Chinese medicine decoction combined with western medicine is better than that of western medicine control group,and the recurrence rate is lower than that of western medicine control group （P〈0.05）.Conclusion Oral Chinese medicine decoction combined with western medicine has some advantages in the treatment of gouty arthritis,compared with western medicine treatment,the recurrence rate is lower.