丹皮酚抗肿瘤作用及其机制研究进展

Research Progress on Antitumor Effect and Mechanism of Paeonol

牡丹皮是中医药临床中的常用药材.长期以来,其主要活性成分丹皮酚(paeonol,pae,2-羟基-4-甲氧基苯乙酮)是药学领域研究的热点.大量研究表明,丹皮酚具有抗肿瘤、保肝护肾、降血糖、抗菌消炎、抗心律失常、抗过敏、保护心血管、保护神经、增强免疫力等多种药理作用.进入21世纪以来,丹皮酚的抗肿瘤作用受到广泛关注.综述了近几年丹皮酚抗肿瘤作用及其机制的研究进展.

Cortex Moutan is one of the commonly-used herbs in clinical practice of Chinese Medicine. Paeonol （Pae, 2-hydroxy-4-methoxyacetophenone） is the major bioactive component of Moutan Cortex, which has become a research hotspot in the pharmaceutical field for many years. A large number of studies have shown that paeonol has anti-tumor, liver and kidney protection, hypoglycemia, anti-bacterial anti-inflammatory, anti-arrhythmia, anti-allergic, cardiovascular protection, nerve protection, enhancing immunity and other pharmacological effects. Since the 21st century, the anti-tumor effect of paeonol has attracted wide attention and this paper reviews the recent research progress in the anti-tumor effect of Paeonol and its mechanism.