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肺抑瘤膏对EGFR野生型Lewis肺癌小鼠肿瘤生长及VEGF表达的影响 被引量:4

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摘要 目的建立Lewis肺腺癌小鼠移植瘤模型,取移植瘤进行表皮生长因子受体(EGFR)基因测序,观察肺抑瘤膏对移植瘤的干预作用。方法使用C57BL/6小鼠,接种Lewis肺腺癌细胞,造模成功后,随机分两组,对照组予生理盐水,干预组予肺抑瘤膏,观察瘤体体积、瘤重,并进行血管内皮生长因子(VEGF)检测及EGFR基因测序。结果两组移植瘤体积、瘤重、肿瘤抑制率、移植瘤生长指数、VEGF表达差异均有统计学意义(均P<0. 05)。EGFR基因测序示非突变型。结论肺抑瘤膏能够明显抑制EGFR非基因突变型肺腺癌移植瘤的生长,且可能通过抑制VEGF表达而起到治疗作用。
出处 《中国老年学杂志》 CAS 北大核心 2018年第19期4719-4721,共3页 Chinese Journal of Gerontology
基金 山东省科技发展计划(2014GSF119015) 济南市科技计划项目(201602185) 山东中医药大学优秀青年科学基金(2018zk35)
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