化浊解毒方治疗胃癌前病变30例

Thirty Cases of Gastric Precancerous Lesions Treated with Formula for Resolving Turbid and Removing Toxicity

目的:观察化浊解毒方治疗胃癌前病变的临床疗效。方法:将60例确诊为胃癌前病变的患者随机分为观察组和对照组,每组各30例。对照组给予胃复春片,观察组在对照组的基础上给予化浊解毒方。比较两组患者的临床疗效、胃镜疗效及幽门螺杆菌(Helicobacter pylori,Hp)阴转率。检测两组患者治疗前后血清癌胚抗原(carcinoembryonic antigen,CEA)水平。结果:临床疗效:对照组有效率为73.3%,观察组有效率为90.0%,两组患者临床疗效比较,差异有统计学意义(P <0.05)。胃镜疗效:观察组有效率为70.0%,对照组有效率为63.3%,两组患者胃镜疗效比较,差异具有统计学意义(P <0.05)。Hp阴转率比较,观察组Hp阴转率为76.2%,对照组Hp阴转率为47.8%,两组患者Hp阴转率比较,差异具有统计学意义(P <0.05)。两组患者治疗后CEA水平低于治疗前,且观察组低于对照组,差异具有统计学意义(P <0.05)。结论:化浊解毒方治疗胃癌前病变具有良好疗效,其机制可能与通过降低血液中肿瘤标记物与胃中Hp的含量有关。

Objective： To observe the clinical curative effect of Formula for Resolving Turbid and Removing Toxicity on gastric precancerous lesions.Methods： Sixty patients diagnosed as precancerous lesions were randomly divided into the observation group and the control group,with 30 cases in each group.The ones in the control group were given Wei Fu Chun Tablets（ WFCT）,and the ones in the observation group were given Formula for Resolving Turbid and Removing Toxicity on the basis of the control group.The clinical efficacy,gastroscopic efficacy and negative conversion rate of Helicobacter pylori（ Hp） were compared between the two groups.Serum carcinoembryonic antigen（ CEA） levels before and after the treatment in two groups were measured.Results： In terms of clinical efficacy： the effective rate of the control group was 73.3%,and that of the observation group was 90%.There was a significant difference in the clinical efficacy between the two groups（ P 〈 0.05）.In terms of efficacy of gastroscopy： the effective rate of the observation group was 70%,while that of the control group was 63.3%.The difference between the two groups was statistically significant（ P 〈 0.05）.The negative conversion rate of Hp in the observation group was 76.2%,and that was 47.8% in the control group.The difference of Hp negative rate in the two groups was statistically significant（ P 〈 0.05）.The CEA level of the two groups after the treatment was lower than that before the treatment,and the observation group was lower than that of the control group,and the difference was statistically significant（ P 〈 0.05）.Conclusion： Formula for Resolving Turbid and Removing Toxicity has a remarkable clinical curative effect on Hp.The mechanism may be related to lowering the tumor markers in blood and Helicobacter pylori in the stomach.