初发2型糖尿病患者中医体质辨识及胰岛β细胞功能分析

Identification of TCM Constitution and Function of Islet β Cells in Patients with Newly Onset Type 2 Diabetes

目的:分析初发2型糖尿病患者中医体质辨识分布及各组患者胰岛β细胞功能特点。方法:119例初发2型糖尿病患者依据《中医体质分类与判定》标准进行中医体质辨识;完善糖化血红蛋白、肝肾功能、血脂及75 g葡萄糖3 h OGTT的检测。结果:初发2型糖尿病患者中气虚质、阴虚质、血瘀质、痰湿质为最常见的体质类型;其中阳虚质患者的胰岛β细胞功能最差,痰湿质及湿热质患者的胰岛素抵抗最严重。结论:社区医师针对2型糖尿病高危人群的管理可使用中医体质辨识,尤其加强对气虚质、阴虚质、血瘀质及痰湿质体质人群管理、教育及治疗,以保护2型糖尿病患者残存的胰岛β细胞功能并减轻胰岛素抵抗。

Objective：To analyze the distribution of TCM constitution and the function of islet 13-cells in patients with type 2 diabe- tes mellitus. Methods ： 119 patients with newly diagnosed type 2 diabetes were identified according to the criteria of Classification and Judgment of TCM Constitution. The detection of glyeosylated hemoglobin,liver and kidney function, blood lipid and 75 g glu- cose 3hOGTF were improved. Results ： Qi deficiency, Yin deficiency, Blood stasis and Phlegm-dampness were the most common types of constitution in patients with newly diagnosed type 2 diabetes. Among them, patients with Yang deficiency had the worst function of islet G-cells, and the insulin resistance is the heaviest in patients with Phlegm-dampness and Damp-heat constitution. Conclusion：Community physicians can use the TCM constitution to identify the high-risk groups of type 2 diabetes, especially to strengthen the management, education and treatment of Qi deficiency, Yin deficiency, Blood stasis and Phlegm -dampness constitu- tion to protect the residual islet beta cells function and reduce insulin resistance of type 2 diabetes patients.