补肾疏肝汤联合调Q激光治疗黄褐斑疗效观察

Clinical Efficacy Observation on Bushen Shugan Decoction Combined with Q-switched Laser in Treating for Chloasma

目的:观察补肾疏肝汤联合调Q激光治疗黄褐斑肝郁肾虚证的临床疗效,以及对血清中超氧化物歧化酶(superoxide orgotein dismutase,SOD)和丙二醛(malondialdehyde,MDA)水平的影响。方法:将120例黄褐斑女性患者按随机数字表法分为治疗组和对照组,每组60例。两组患者均根据《中国黄褐斑治疗专家共识(2015)》采用常规维生素治疗。对照组采用调Q激光治疗,每月1次。治疗组在对照组治疗基础上加用补肾疏肝汤治疗,每天1剂,每天2次。两组患者均连续治疗6个月。治疗后观察两组患者皮损评分、生存质量测定量表简表(quality of life scale,OQOL-BREF)评分和临床疗效。检测两组患者血清中SOD和MDA水平。结果:治疗后,治疗组患者的皮损面积和皮损颜色评分均明显低于对照组,差异均有统计学意义(P<0.01);治疗后患者治疗组WHOQOL-BREF评分较对照组升高更明显,差异有统计学意义(P<0.01);治疗组有效率为83.33%,明显高于对照组71.67%,差异有统计学意义(P<0.05);治疗后与对照组比较,治疗组血清中SOD水平升高更明显,MDA水平下降更明显,差异均有统计学意义(P<0.01)。结论:补肾疏肝汤联合调Q激光治疗黄褐斑郁肾虚证疗效显著,其改善患者体内SOD水平和MDA水平可能是其疗效途径。

Objective：To observe the clinical efficacy of Bushen Shugan Decoction combined with Q-switched laser in treatment of Chloasma with Liver Qi stagnation and Kidney deficiency Syndrome and the effect on hypertrophic dismutase （SOD） and malondi- aldehyde （MDA） levels in serum. Methods ：120 female patients with Chloasma were randomly divided into treatment group and control group, with 60 cases in each group. Both groups of patients were treated with conventional vitamins according to Chinese Chloasma Treatment Expert Consensus （2015）. The control group was treated with Q-switched laser once a month. The treatment group was treated with Bushen Shugan Decoction in addition to that of the control group,with 1 dose per day,2 times a day. Both groups of patients were treated continuously for 6 months. After treatment, the skin lesion score, the quality of life measurement scale （WHOQOL-BREF） score and clinical efficacy were observed. Serum levels of SOD and MDA were measured in both groups. Results ： After treatment, the skin lesion area and skin lesion color score of the treatment group were significantly lower than that of the control group （P 〈 0.01 ）. Compared with that of the control group, the WHOQOL-BREF score was significantly higher in the treatment group （ P 〈 0.01 ）. The effective rate of the treatment group was 83.33%, which was significantly higher than that （71.67%） of the control group （P 〈 0.05 ）. Compared with that of the control group, the serum level of SOD was more signifi- cantly and MDA decreased more significantly in the treatment group （ P 〈 0.01 ）. Conclusion ： Bushen Shugan Decoction combined with Q-switched laser is effective in treating for Chloasma with Liver Qi stagnation and Kidney deficiency Syndrome. It may be one of the effective ways to improve SOD and MDA levels in patients.