跨膜蛋白受体PTCH1基因与肺癌的关系研究进展

Research progress of the relation between PTCH1 gene and lung cancer

肺癌的发病率和病死率较高,是当前我国重要的公共健康问题。近年来随着分子生物学发展及精准医学基因靶向治疗取得新突破,肺恶性肿瘤的治疗由传统放化疗逐渐转向基因靶向治疗。跨膜蛋白受体PTCH1基因是近年来研究发现与肺癌发病密切相关的基因之一,该基因的突变或表达低下与肺癌的发生、转移与增殖密切相关。因此,深入研究PTCH1基因在肺癌致病中的作用机制,对肺癌的基因精准靶向治疗具有一定的指导意义。

Lung cancer, with high incidence and mortality, has become an important public health problem in China. Recently researches on molecular biology and precision medicine have made new breakthroughs, which make the change in treatment of lung malignant neoplasms from traditional chemoradiotherapy to gene target therapy. PTCH1 gene is closely related to the occurrence, metastasis and proliferation of lung cancer. This paper discussed the mechanism of PTCH1 genc in the pathogenesis of lung cancer.