益生菌与妊娠糖尿病的相关性

Relationship between probiotics and gestational diabetes mellitus

妊娠糖尿病是当前影响母婴健康结局的重要因素之一,其发病率日渐上升,对母婴健康产生深远影响.目前治疗主要为饮食控制、运动疗法和胰岛素治疗.研究表明,肠道菌群可调节母体免疫、代谢、发挥抗炎作用,并可改善肠道微环境,其有望成为防治妊娠糖尿病的新手段.了解与妊娠糖尿病发展相关的肠道菌群变化、益生菌对妊娠期糖、脂代谢的影响及益生菌对抗妊娠糖尿病的病理生理机制,有助于将益生菌作为防治妊娠糖尿病的新策略.

Gestational diabetes mellitus is one of the important factors affecting the maternal and child health outcomes at present.The incidence of gestational diabetes mellitus is increasing day by day and has a profound impact on maternal and child health.At present,the treatment mainly includes diet control,exercise therapy and insulin therapy.Studies have shown that the intestinal flora could regulate maternal immunity,metabolism,exert anti-inflammatory effects and improve the intestinal micro-environment,which was expected to become a new means of preventing and treating gestational diabetes mellitus.Understanding the changes of intestinal flora associated with the development of gestational diabetes mellitus,the effect of probiotics on glucose and lipid metabolism during pregnancy and the pathophysiological mechanisms of probi otics against gestational diabetes mellitus can help us to use probiotics as a new strategy for the prevention and treatment of gestational diabetes mellitus.