摘要
小檗碱是异喹啉类生物碱,主要从黄连中提取,最初作为清热和抗菌药物广泛用于治疗肠胃炎、细菌性痢疾等.研究发现,其有着广泛的药理作用,如降低血脂,改善胰岛素抵抗等.最新研究表明,小檗碱可通过激活AMP活化蛋白激酶信号通路、胰岛素受体底物及调节肠道菌群等改善胰岛素抵抗.小檗碱可能成为治疗糖尿病胰岛素抵抗的重要药物之一.
Berberine is isoquinoline alkaloid,which is mainly extracted from Coptischinensis.They were originally used in clinical practice as antipyretics and antimicrobial agents to treat gastroenteritis,bacte rial dysentery and so on.It has been found with a wide range of pharmacological effects,such as lowering blood lipids,improving insulin resistance.Recent studies have shown that bererine can reduce insulin resist ance by activating the adenosine 5＇-monophosphate （AMP）-activated protein kinase signaling pathways and insulin receptor substrate（IRS）,adjusting gut microbiota.Berberine may be an important potential drug for treating patients with diabetesing.
作者
万仕炜
郁梅
方彭华
张真稳
Wan Shiwei;Yu Mei;Fang Penghua;Zhang Zhenwen(Experiment Center of Basic Medicine,Nanjing University of Chinese Medicine Hanlin College,Taizhou 225300,China)
出处
《国际内分泌代谢杂志》
2018年第5期333-335,共3页
International Journal of Endocrinology and Metabolism
基金
江苏省大学生创新创业训练计划项目（201613981012X）
江苏省中医药管理局科研项目（YB201518）
江苏省六大人才高峰课题（WSN-113）
泰州市科技支撑项目（TS201723）
