解聚蛋白样金属基质蛋白酶-7在心血管疾病治疗新靶点中的研究进展

ADAMTS-7—A New Target for Cardiovascular Diseases Treatment

解聚蛋白样金属基质蛋白酶(a disintegrin-like and metalloprotease,ADAMTS)是含有I型血小板结合蛋白基序的多结构域分泌型蛋白。含有Ⅰ型血小板结合蛋白基序的ADAMTS-7为ADAMTS家族重要一员,在心血管疾病中扮演着重要的角色。ADAMTS-7在生理状态下参与机体的生长发育,病理状态ADAMTS-7过表达,通过降解软骨寡聚基质蛋白(COMP)等细胞外基质从而参与多种心血管疾病的发生发展。同时转化生长因子(TGF)-β、miRNA29a/b可以有效的抑制ADAMTS-7的过表达,进而有效抑制心血管疾病的发展。笔者主要对ADAMTS-7的基因结构、蛋白功能及其在心血管涉及的作用机制进行回顾阐述,并展望ADAMTS-7作为治疗心血管疾病新靶点的可能性。

A disintegrin-like and metalloprotease （ADAMTS） proteinases are a group of muhidomains and secreted metalloproteinases containing the thrombospondin motifs. ADAMTS-7 is a member of ADAMTS family and plays a crucial role in the cardiovascular diseases. In physically, ADAMTS-7 was involved in the growth and development of the body. However, in pathological conditions, over expression of ADAMTS-7 gene accelerated the progression of cardiovascular diseases through by promoting the breakdown of cartilage oligomeric matrix protein （COMP） matrix. Meantime, the over expression of ADAMTS-7 can be effectively inhibited by TGF-β, miR- NA29a/b, and then effectively retarded the development of cardiovascular disease. This article mainly reviews the gene structure, pro-tein function and the mechanism of ADAMTS-7 involved in cardiovascular diseases and looks forward to the possibility of ADAMTS-7 as a new target for the treatment of cardiovascular diseases.