美国NBP项目与我国生物监测分析及思考

Analysis and Thoughts on Biomonitoring of US National Biomonitoring Program

目的了解美国NBP项目人群生物监测工作,为我国生物监测工作提供借鉴。方法依据美国《国家环境化学物质人体暴露报告》及项目实验室程序手册,对美国NBP项目监测指标、样本及实验技术等内容进行调查分析。结果调查表明,NBP项目采用不同类型的固相萃取技术、串联质谱及高分辨质谱与不同色谱的联用技术对人群生物样本中的296种化学物质或代谢物进行了暴露监测,其中约85%的监测项目达到超痕量水平。结论生物监测是环境与健康风险评估的重要基础和组成部分,我国生物监测指标、标准、规范、质控等方面还存在一定的差距,生物监测基础研究工作有待进一步加强。

Objectives To understand the status and characteristics of biological monitoring and analysis of US NBP project and provide some suggestions for the biological monitoring work in China. Methods Based on US Fourth National Report on Human Exposure to Environmental Chemicals and the programLaboratory Procedure Manual,the monitoring indicators,samples and experimental techniques of NBP project were investigated and analyzed. Results Investigation showed that the NBP project exposed 296 chemicals or metabolites in the population biological samples by using different types of solid phase extraction technology and high resolution mass spectrometry,tandem mass spectrometry and the combination of different chromatographic technology,of which about 85% of the monitoring project to ultra-trace levels. Conclusions Biological monitoring is the important foundation of environmental and health risk assessment and there are still some gaps in part of biological monitoring standard,specification,quality control in our country,the basic research work of biological monitoring remains to be further strengthened.