摘要
Cardiovascular disease（CVD） vemains the leading global cause of the death. Genetic polymorphisms in NKX 2-. are found to be associated with CVD. However, the results were inconsistent and inconclusive. The present study performed a meta-analysis to get a more precise and comprehensive estimation of the association between the genetic polymorphisms in NKX 2-5 and the risk of CVD. The databases Pubmed, Chinese National Knowledge Infrastructure （CNKI）, Wanfang Data and CQVIP were searched for related studies. A total of 9 studies including 1516 cases and 1438 controls were identified for the meta-analysis. The results indicated that the genetic polymorphisms in NKX 2-5 were associated with the significantly risks of CVD in the allelic model, dominant model, codominant model and superdominant model of rs3729753（OR=1.94,2.00,2.00 and 0.50 respectively） and rs118026695（OR=1.83,1.98,2.02 and 0.49 respectively）.No significant associations were found between rs2277923 and g.1467G〉A and CVD susceptibility in any of the studies. Therefore, rs3729753 and rs118026695 might be recommended as a predictor for the risk of CVD, while rs2277923 and g.1467G〉A are not.
