不同分子亚型乳腺癌危险因素分析

Analysis on Risk Factors of Different Molecular Subtypes of Breast Cancer

乳腺癌已成为当今社会重大的公共卫生问题,是全球女性最常见的恶性肿瘤之一。乳腺癌的病因较为复杂,目前常见的影响因素有内源性雌激素暴露、生育史、乳腺良性疾病、遗传因素、生活行为习惯等。乳腺癌具有高度异质性,分子亚型包括Luminal A、Luminal B、人类表皮生长因子受体2过表达及三阴性。通过研究影响不同分子亚型乳腺癌发病的危险因素,有助于乳腺癌的预防、治疗及改善预后。但目前部分危险因素对不同分子亚型乳腺癌的影响尚无定论,后续可开展前瞻性、大样本、多中心的随访研究进行验证。

Breast cancer has become a major public health problem in today＇s society- , which is one of the major malig- nant tumors that harms the global women＇s health. The causes of breast cancer are complex, and the common factors are endogenous estrogen exposure, birth history, benign breast diseases, genetic factors, living habits and so on. Breast cancer has a high degree of heterogeneity, and the molecular subtypes include Luminal A, Luminal B, human epidermal growth fac- tor receptor 2 overexpression and triple-negative type. Study of the risk factors of different molecular subtypes are helpful to prevent, treat and improve the prognosis of breast cancer. However, the effect of some risk factors on different molecular subtypes has not been determined,which needs to be verified by prospective,large sample and multicenter follow-up studies.