摘要
山豆根被誉为治疗咽喉肿痛的第一要药,临床应用广泛。因山豆根毒效并存,临床常因不合理应用导致一系列的安全问题,结合近30年文献报道,剖析山豆根产生毒性反应的根本原因,并从化学成分的角度探讨其发挥药效及产生毒性的实质,对如何促进山豆根临床合理应用提出探索性的思考。
Sophorae Tonkinensis Radix et Rhizoma is known as the important drug for treating sore throat and is widely used in clinic. Because of the coexisting of its efficacy and poison, Sophorae Tonkinensis Radix et Rhizoma often leads to a series of safety problems in the clinical application process. In this study, we attempt to analyze the ultimate cause of the toxicity of Sophorae Tonkinensis Radix et Rhizoma by reviewing nearly 20 years of literature, discuss the substance of its efficacy/toxicity from the point of view of chemical composition, and put forward exploratory thinking on its clinical rational application.
作者
聂安政
赵雪睿
高梅梅
钞艳惠
李肖
桂新景
朱春胜
张冰
NIE An-zheng;ZHAO Xue-rui;GAO Mei-mei;CHAO Yan-hui;LI Xiao;GUI Xin-jing;ZHU Chun-sheng;ZHANG Bing(The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;The Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China;School of Chinese Material Medica,Beijing University of Chinese Medicine,Beijing 100029,China)
出处
《中草药》
CAS
CSCD
北大核心
2018年第17期4152-4161,共10页
Chinese Traditional and Herbal Drugs
基金
国家自然科学基金资助项目(81673618
81403152)
教育部高等学校博士学科点专项科研基金(20120013130002
20130013120001)
关键词
山豆根
安全问题
合理用药
毒效并存
毒性反应
苦参碱
氧化苦参碱
槐果碱
氧化槐果碱
Sophorae Tonkinensis Radix et Rhizoma
security issues
rational use of drugs
coexisting of efficacy and poison
toxic reaction
matrine
oxymatrine
sophocarpine
oxysophocarpine