摘要
对香豆酸主要存在于水果、蔬菜、谷物和真菌中,在中药中含量也很丰富。对香豆酸具有抗氧化、抗炎、免疫调节、抗肿瘤、抗血小板聚集、保护心血管、预防和改善糖尿病及神经保护作用。抗氧化活性是对香豆酸其他药理作用的基础。另外,对香豆酸对细菌有一定的抑制作用,还可抑制黑色素形成及延缓皮肤老化。对对香豆酸的主要药理作用进行综述,为药食两用资源的开发研究提供借鉴。
p-coumaric acid is mainly found in fruits, vegetables, grains, and fungi, and is also abundant in Chinese herbal medicines. The pharmacological effects of p-coumaric acid has anti-oxidant, anti-inflammatory, immunomodulatory, antitumor effects, antiplatelet aggregation, cardiovascular protection, prevention and improvement of diabetes, and neuroprotection, while the anti-oxidant activities of p-coumaric acid is the important basis of other pharmacological effects. In addition, p-coumaric acid has a certain inhibitory effect on bacteria, and also can inhibit melanin formation and delay skin aging. This paper reviews the main pharmacological effects of p-coumaric acid and provides reference for the development of both medicinal and food resources.
作者
管西芹
毛近隆
唐迎雪
王集会
孙蓉
GUAN Xi-qin;MAO Jin-long;TANG Ying-xue;WANG Ji-hui;SUN Rong(College of Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;College of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Experimental Centre,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;College of Qilu Medical,Shandong University,Jinan 250014,China)
出处
《中草药》
CAS
CSCD
北大核心
2018年第17期4162-4170,共9页
Chinese Traditional and Herbal Drugs
基金
山东省重点研发计划项目(2016GSF202034)
山东省高等学校科技计划项目(J16LM53)
山东省中医药科技发展计划项目(2015-023)
山东省泰山学者工程专项经费资助(ts 201511107)
山东中医药大学中药理论应用及药效筛选平台(220321)
关键词
对香豆酸
抗氧化
抗炎
抗肿瘤
保护心血管
糖尿病
p-coumaric acid
anti-oxidant activity
anti-inflammation
antitumor
cardiovascular protective effect
diabetes
