表皮细胞生长因子联合复方多粘菌素B对老年深Ⅱ度烧伤病人创面瘢痕的疗效分析

Clinical effect of epidermal growth factor combined with polymyxin B for wound scar in elderly patients with deep second-degree burns

目的探讨表皮细胞生长因子(EGF)联合复方多粘菌素B治疗老年深Ⅱ度烧伤病人创面瘢痕的疗效。方法选取120例老年深Ⅱ度烧伤病人,随机分为观察组和对照组,每组60例。对照组采用复方多粘菌素B治疗,观察组采用复方多粘菌素B联合EGF治疗。比较2组老年病人的创面愈合时间、愈合率、瘢痕发生率、创面细菌清除率以及疼痛视觉模拟评分(VAS)。结果观察组创面愈合时间显著低于对照组,7、14、21 d创面愈合率均高于对照组,差异具有统计学意义(P<0.05)。观察组瘢痕发生率、瘢痕量表评分均低于对照组,差异具有统计学意义(P<0.05),2组间创面细菌清除率差异无统计学意义。观察组7、14、21 d VAS疼痛评分均低于对照组(P<0.05)。结论复方多粘菌素B与EGF联合治疗老年深Ⅱ度烧伤病人,具有促进创面愈合、降低创面感染风险、减少疼痛的优势,适用于临床。

Objective To investigate the effect of epidermal growth factor（EGF） combined with polymyxin B on the wound scar in the elderly patients with deep second-degree burns. Methods A total of 120 elderly patients with deep second-degree burns were selected and randomly divided into observation group and control group,with 60 cases in each group. The patients of control group were treated with compound mucopolysaccharide B,and the patients of the observation group were treated with compound mucopolysaccharide B and EGF. The wound healing time,healing rate,incidence rate of scar,wound bacterial clearance and VAS pain score were compared between the two groups. Results The wound healing time was significantly lower, and the wound healing rate 7, 14, 21 d later was significantly higher in the observation group than that in the control group（ P〈0. 05）. The incidence rate of scar formation and the scar scale score in the observation group were lower than those in the control group（ P〈0. 05）. The bacterial clearance rate showed no significant difference between two groups（ P〉0. 05）. The pain scores of VAS in the observation group 7 d,14 d and 21 d later were significantly lower than those in the control group（ P〈0. 05）. Conclusions The combination of compound mucopolysaccharide B and EGF in the treatment of deep second-degree burns in the elderly patients has the advantages in promoting wound healing,reducing the risk of wound infection and reducing pain,and is suitable for clinical application.