IRF6基因多态性与非综合征型唇腭裂相关性的meta分析

A meta-analysis about correlation between IRF6 gene polymorphism and non-syndromic cleft lip with or without cleft palate

目的用meta分析的方法定量评价IRF6基因rs2235371位点单核苷酸多态性(SNPs)与中国非综合征型唇腭裂患者的相关性。方法利用计算机检索PubMed、VIP、CNKI和WanFang Date数据库自建库以来至2016年2月公开发表的文献。两位研究者独立按照纳入和排除标准筛选文献、提取资料。并且用Stata12.0软件对提取的数据进行meta分析。结果共有7个病例-对照研究符合纳入标准,包括969例患者和783例对照。meta分析结果显示:GA vs GG:P=0.000,OR=0.629(95%CI:0.519～0.762);GA+AA vs GG:P=0.000,OR=0.615(95%CI:0.512～0.738),有统计学意义,提示GA和GA+AA型可降低罹患非综合征型唇腭裂的风险。AA vs GG:P=0.063,OR=0.598(95%CI:0.349～1.025);GA+GG vs AA:P=0.304,OR=1.355(95%CI:0.794～2.312),无统计学意义。结论 IRF6基因rs2235371位点SNPs与非综合征型唇腭裂存在相关性,GA和GA+AA型可降低中国人罹患非综合征型唇腭裂的风险。

Objective To explore the association between IRF6 rs2235371 polymorphism and susceptibility ot non-syndromie cleft lip with or without cleft palate, NSCL/P. Methods The studies were screened according to the inclusion and exclusion criteria from PubMed, CNKI, VIP, Wanfang Database （up to 2016.02）, and the date were extracted. Software STATA 12.0 was used for all analysis. Results A total of 7 studies were included （969 cases and 783 controls）. When all the studies were pooled, GAvs GG：P=0.O00, OR=0.629 （95%CI：0.519-0.762）; GA＋AA vs GG：P=0.000, OR=0.615 （95%CI：0.512-0.738）, The genotypes GA and GA＋AA decreased the NSCIzP risk Of Chinese. AA vs GG： P=0.063, OR=0.598 （95%CI：0.349-1.025）; GA＋GG vs AA：P=0.304, OR=1.355 （95% CI：0.794-2.312）, no significant difference. Conclusion The Meta analysis suggests that IRF6 rs2235371 allele is associated with high risk of NSCL/P.