摘要
东南亚作为间日疟全球最为高发的地区,占据了全世界发病总人数的74%。相关研究表明,世界卫生组织推荐的包括氯喹在内的抗间日疟药物已在马来西亚等地区出现了抗药性,给当地的疟疾防控带来了巨大挑战。本文针对抗间日疟常用药物抗药性的发生机制研究进展进行综述。
As the area with the highest incidence of Plasmodium vivax,Southeast Asia accounts for 74% of all cases worldwide.Relevant studies have indicated that P.vivaxis developing resistance to anti-malaria drugs recommended by the World Health Organization（including chloroquine）in areas such as Malaysia,posing a major challenge to local malaria prevention and control.This article reviews advances in the study of the mechanism by which P.vivaxdevelops resistance to common anti-malarial drugs.
作者
刘怀鄂
苏品璨
陈熙
李翠英
吴艳瑞
孙乐
杨照青
LIU Huai-e;SU Pin-can;CHEN Xi;LI Cui-ying;WU Yan-rui;SUN Le;YANG Zhao-qing(Department of Microbiology and Immunology,Kunming Medical University,Kunming 650500,China;Department of Infectious Diseases,The First Hospital affiliated with Kunming Medical University;Blood Transfusion Laboratory,Kunming Blood Center,Yunnan Province;Department of Cell Biology and Medical Genetics,Kunming Medical University)
出处
《中国病原生物学杂志》
CSCD
北大核心
2018年第9期1049-1051,F0003,共4页
Journal of Pathogen Biology
基金
国家自然科学基金项目(No.31260508
U1202226)
云南省卫生和计划生育委员会医学后备人才培养项目
云南省博士新人奖项目
关键词
疟原虫
间日
药物
抗药性
综述
Plasmodium vivax
drug
drug resistance
review
