老年冠心病患者PCI术后冠脉再狭窄与Lox-1表达及其免疫学指标关联性研究

Correlation Between Coronary Restenosis and Lox-1 Expression and Immunological Markers in Elderly Patients with Coronary Heart Disease after PCI

经皮冠状动脉介入治疗(PCI)手术是老年冠心病(CHD)患者治疗的常用术式之一,但实际临床应用中有一定几率发生冠状动脉再狭窄。人凝集素样氧化低密度脂蛋白受体(Lox-1)被认为与动脉粥样硬化的斑块形成有关。为研究Lox-1在冠脉再狭窄中存在贡献,本研究选取了近4年的行PCI术的老年CHD患者662例作为研究对象以及老年健康人进行血清Lox-1检查。研究发现Lox-1可以作为老年CHD患者PCI术后发生再狭窄的诊断指标,且Lox-1激活NF-κB信号通路加速斑块形成,激活心肌细胞凋亡,可能是老年CHD患者PCI术后再狭窄发生的机制。

Percutaneous coronary intervention （PCI） is one of the common surgical procedures for the treatment of elderly patients with coronary heart disease （CHD）, but there is a certain chance of coronary artery restenosis in actual clinical application. Human lectin-like oxidized low density lipoprotein receptor 1 （Lox-1） is thought to be involved in atherosclerotic plaque formation, but whether it is coronary artery after PCI and it is unclear what plays a role in restenosis. In order to study the contribution of Lox-1 in coronary restenosis, 662 elderly patients with CHD who underwent PCI in the past 4 years were selected as subjects and elderly volunteers were tested for serum Lox-1. Lox-1 can be used as a diagnostic marker for restenosis after PCI in elderly patients with CHD, and Lox-1 activates NF-κB signaling pathway to accelerate plaque formation and activate cardiomyocyte apoptosis, possibly in elderly patients with CHD after PCI.