脑-肠-微生物轴与抑郁症研究进展

Research Progress on Relationship Between Depression and Brain-gut-microorganism Axis

随着现代社会生活压力的逐渐增大,抑郁症的发病率也在不断的提高。医学与社会学的进步使得我们对抑郁症的认识不断深化,诊断率也随之上升。抑郁症的发病原因至今不明,且传统疗法存在诸多限制,如许多患者对于药物副作用无法耐受,结合认知心理治疗价格昂贵,导致患者依从性差。近年来发现脑-肠-微生物轴通过神经、内分泌、免疫等途径对抑郁症的发病及进展有着深远影响。现将脑-肠-微生物轴与抑郁症的关系作一研究进展综述,希望为临床开辟新的诊疗思路。

With high levels of pressure in social life,the morbidity of depression has been raised nowadays. The development of clinical medicine and sociology give us a chance to learn more about this, therefore, the diagnosis rates has been increased. The cause of depression is unclear, at the same time, the traditional therapy has a lot of restrictions. For example, a lot of medicine has side effects that many patients can＇t bear and counseling guidance is expensive that a lot of them can＇t afford it. Brain-gut-microorganism axis has a deep impact on the development of depression through neural, endocrine and immune pathway. The paper focuses on the progress of the relationship between brain-gut-microorganism axis and depression, wishing create a new idea for clinical work.