磁共振PWI技术对重型颅脑外伤高压氧干预时脑血流状态评价的临床应用价值研究

Research on clinical application value of MRI PWI technology evaluating brain blood state in severe brain injury with hyperbaric oxygen intervention

目的探讨磁共振灌注成像(perfusion weighted imaging,PWI)技术在重型创伤性脑损伤(traumatic brain injury,TBI)高压氧(hyperbaric oxygen,HBO)干预时脑血流状态评价的临床应用价值。材料与方法选择20例重型颅脑外伤患者(GCS≤8分),分为高压氧治疗和非高压氧治疗对照组,比较两组之间各时间段的脑磁共振PWI图像脑血流量(cerebral blood flow,CBF)及脑血容量(cerebral blood volume,CBV)值的差异;通过CBF及CBV值来评价高压氧干预治疗下脑外伤疗效,预测TBI预后。结果高压氧治疗组PWI图像的CBF及CBV值明显优于对照组,差异具有显著性(P<0.05)。结论重型颅脑外伤配合高压氧治疗对脑组织损伤部位的恢复以及局部血流的再通及血容量的恢复具有非常重要的促进作用。磁共振PWI技术对重型脑外伤高压氧干预时脑血流状态的评价具有非常高的临床应用价值。

Objective： The aim of the current study is to explore the clinical application value of magnetic resonance imaging perfusion weighted imaging（PWI） technology evaluating brain blood state in traumatic brain injury（TBI） with hyperbaric oxygen（HBO） intervention. Materials and Methods： We selected 20 patients with severe brain injury who were then devided into hyperbaric oxygen therapy group and nonhyperbaric oxygen therapy group. Compared the difference of the cerebral blood flow（CBF） and the cerebral blood volume（CBV） on MRI PWI between the two groups in time intervals. Evaluated the therapeutic effect of hyperbaric oxygen intervention in severe brain injury according to CBF and CBV,and then predicting TBI prognosis. Results： The CBF and CBV values of the PWI images in HBO group were significantly better than control group,the difference was statistically significant（P〈0.05）. Conclusions： Severe brain injury with hyperbaric oxygen intervention has a stimulative effect on the recovery of brain injury,recanalization of local blood flow,and recovery of blood volume. MRI PWI technology has high clinical application value in severe brain injury with HBO intervention.