血管紧张素Ⅱ、血管紧张素(1-7)水平与急性冠状动脉综合征相关性被引量：6

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摘要目的探讨血管紧张素Ⅱ(AngⅡ)、血管紧张素(1-7)[(Ang(1-7)]与急性冠状动脉综合征(ACS)的相关性。方法采用前瞻性研究方法,收集ACS患者134例,同时选取健康人群30例作为对照组。检测所有患者血浆AngⅡ、Ang(1-7)水平及血清肌钙蛋白I(cTnI)水平。比较ACS各分型组间上述指标差异,评价AngⅡ、Ang(1-7)对于ACS患者心肌梗死的诊断价值,并分析上述指标与ACS的相关性。结果 AngⅡ、Ang(1-7)与cTnI在不稳定型心绞痛(UAP)、非ST段抬高型心肌梗死(NSTEMI)、ST段抬高心肌梗死(STEMI)及正常对照组之间差异存在统计学意义(P <0. 01); AngⅡ、Ang(1-7)与cTnI呈正相关(P <0. 01),AngⅡ、Ang(1-7)及cTnI对于ACS患者心肌梗死均具有诊断价值(P <0. 01),cTnI尤为显著,进一步绘制ROC曲线提示AngⅡ、Ang(1-7)及cTnI诊断界值分别为:51. 23pg/ml、42pg/ml及0. 3ng/ml(P <0. 01),AngⅡ、Ang(1-7)对于ACS患者心肌梗死的诊断效能优于cTnI(P <0. 05),而AngⅡ与Ang(1-7)之间差异无统计学意义(P> 0. 05)。结论不同分型ACS患者AngⅡ、Ang(1-7)及AngⅡ/Ang(1-7)比值有统计学意义,AngⅡ、Ang(1-7)对于ACS患者病情评估具有指导意义。

作者刘静杨润华

机构地区南京中医药大学附属南京市中西医结合医院急诊科

出处《心脑血管病防治》 2018年第5期391-393,共3页 CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT

关键词急性冠状动脉综合征血管紧张素类肌钙蛋白I 相关性

分类号 R54 [医药卫生—心血管疾病] R446.1 [医药卫生—诊断学]

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