摘要
As the chemotherapeutic resistance of extranodal NK/T-cell lymphoma(ENKTL) rises year by year, searching for novel chemoprevention compounds has become imminent. Gambogic acid(GA) has recently been shown to have anti-tumor effects, but its role and underling mechanism in ENKTL are rather elusive. In the present study, we showed that GA inhibited the cell growth and potently induced the apoptosis of ENKTL cells in vitro in a time-and concentration-dependent manner. Furthermore, GA induced cell death through endoplasmic reticulum stress(ERS) mediated suppression of Akt signaling pathways and finally the release of the caspase-3 proteases. Overall, our data provided evidences supporting GA as a potential therapeutic agent for ENKTL, which may facilitate further preclinical development of anti-tumor drugs.
As the chemotherapeutic resistance of extranodal NK/T-cell lymphoma（ENKTL） rises year by year, searching for novel chemoprevention compounds has become imminent. Gambogic acid（GA） has recently been shown to have anti-tumor effects, but its role and underling mechanism in ENKTL are rather elusive. In the present study, we showed that GA inhibited the cell growth and potently induced the apoptosis of ENKTL cells in vitro in a time-and concentration-dependent manner. Furthermore, GA induced cell death through endoplasmic reticulum stress（ERS） mediated suppression of Akt signaling pathways and finally the release of the caspase-3 proteases. Overall, our data provided evidences supporting GA as a potential therapeutic agent for ENKTL, which may facilitate further preclinical development of anti-tumor drugs.
基金
supported by the National Natural Science Foundation of China(Nos.81502588 and 81370673)
Agency of Jiangsu Province Science and Technology(Nos.2013035 and BK20151018)
the Key Medical subjects of Jiangsu Province(No.BL2014078)
Research Office of Jiangsu Cancer Hospital(No.ZK201401)
the Key Discipline of Jiangsu Province(2016-2020)
