胃癌组织中NDRG3的表达及其与预后的关系

Relationship between NDRG3 and prognosis in gastric cancer

目的:探讨N-myc下游调控基因家族(N-myc downstream-regulated gene,NDRG) 3在胃癌组织中的表达情况及其与胃癌患者预后的关系。方法:应用免疫组化染色研究NDRG3在胃癌组织中的表达,并分析其与胃癌患者预后的关系。结果:NDRG3主要表达在细胞质中,在细胞核中也有少量表达。在60例胃癌组织中,42例高表达,阳性率为70%,明显高于癌旁组织。临床病理资料分析显示NDRG3表达与胃癌的淋巴结转移相关(P <0. 05),且NDRG3高表达患者较低表达患者预后差(P <0. 05)。结论:NDRG3在胃癌组织中较癌旁组织高表达,且其表达水平与胃癌淋巴结转移及患者预后相关,提示NDRG3与胃癌转移机制密切相关,为胃癌诊治提供了新的思路。

Objective The aim of our study was to investigate the relationship between expression of NDRG3 and clinicopathological features in gastric cancer,and to evaluate its correlation with prognosis. Methods： Immunohistochemistry was used to measure the expression of NDRG3 in gastric cancer,and then the relationship between expression levels of NDRG3 and prognosis in gastric cancer was analyzed. Results： NDRG3 was mainly expressed in cytoplasm,few in nucleus.There were 42 high expression in 60 cases gastric cancer tissues,and the positive rate was 70%,was significantly higher than para-cancer tissues.There was a significant relationship between expression level of NDRG3 and metastasis of lymph nodes （ P 〈0.05）.The results of Kaplan-Meier survival analysis indicated that high expression of NDRG3 were associated with a worse survival （ P 〈0.05）. Conclusion： Expression level of NDRG3 in gastric cancer tissue was higher than para-cancer tissues.Expression level was correlated with lymph node metastasis and prognosis of gastric cancer patients,suggesting that NDRG3 was closely related to gastric cancer metastasis mechanism.Our result provided a new idea for the diagnosis and treatment of gastric cancer.