DNA甲基化与消化系统恶性肿瘤的关系

Relationship between DNA methylation and digestive system malignant tumors

DNA甲基化是指以S-腺苷甲硫氨酸为甲基供体（SAM），在DNA甲基转移酶（DNMT）的作用下，将甲基基团添加到CpG二核苷酸5′端的胞嘧啶上，形成5．甲基胞嘧啶（5-mC）。DNA甲基化作为常见的表观遗传学事件之一，在肿瘤的诊断及治疗中发挥关键作用，日渐成为相关肿瘤的研究热点。消化系统恶性肿瘤是全世界癌症相关死亡的主要原因，目前尚缺乏早期诊断手段。文章就DNA甲基化与消化系统恶性肿瘤之间的关系作一综述。

DNA methylation refers to the use of S-adenosylmethionine as a methyl donor （hAM）, in the role of DNA methyhransferases （DNMT）, the methyl group added 5-methylcytosine （5-mC） was formed on the cytosine of 5′ terminal CpG dinucleotide. DNA methylation is one of the common epigenetic events,play a key role in the diagnosis and treatment of tumors, increasingly become a hot topic of related tumors. Digestive system tumors is the main cause of cancer-related death worldwide, and there is a lack of early diagnosis. This article provides a brief overview of the relationship between DNA methylation and digestive system malignant tumors.