甲型流感易感基因单核苷酸多态性的研究进展

Advances in single nucleotide polymorphism of susceptibility genes in influenza A

甲型流感病毒是造成季节性流感及历史上流感大流行的主要病毒类型,受到国内外研究者的广泛关注,中国也被公认为新型流感病毒的首发地、多发地,是世界流感监测的前哨,我国流感监测工作在全球起着举足轻重的作用。研究人员利用功能基因组学筛选及病例对照研究,发现多种基因通过不同致病机制影响人类感染流感病毒或加重流感患者病情,宿主基因变异会影响甲型流感的毒性及传播能力,对流感易感性有很大影响。开展甲型流感相关易感基因的研究,从宿主遗传水平探讨甲型流感的发病机制,有助于进一步探索流感病毒入侵宿主的致病机制,从而促进对流感的研究和防治工作的开展。

Influenza A virus is the main type of seasonal influenza and influenza pandemics in history. It has been widely researched at home and abroad. China has also been recognized as a new and multiple influenza virus place, which is also the outpost of world influenza surveillance. Influenza surveillance in China plays an important role in the world. The researchers use functional genomics screening and case-control study to find some genes which can affect the hmnan influenza virus infection or aggravate the condition of patients with influenza through a variety of pathogenic mechanisms. Mutation of the host gene can affect the toxicity and the spreading of influenza A virus, which also has great effects on susceptibility to influenza. The study on susceptibility gene of influenza A, at the level of host genetic to find the pathogenesis of influenza A, in order to further explore the pathogenesis of influenza virus invasion of the host ,which contributes to carry out influenza prevention and control work.