顺铂联合氟尿嘧啶同步放化疗治疗中晚期宫颈癌的临床效果

Clinical effect of cisplatin combined with fluorouracil concurrent chemoradiotherapy in the treatment of advanced cervical cancer

目的探讨同步放化疗治疗中晚期宫颈癌的临床效果。方法将2016年11月至2018年5月本院的80例中晚期宫颈癌患者随机分为对照组和试验组,各40例,对照组给予单纯放疗治疗,试验组给予顺铂联合氟尿嘧啶同步放化疗治疗,比较两组的治疗效果。结果试验组患者的治疗有效率显著高于对照组,胃肠道毒副作用轻于对照组(P<0.05)。治疗后,两组患者CD3^+、CD4^+水平及CD4^+/CD8^+均显著降低(P<0.05),但组间差异不显著(P>0.05)。试验组5年内的生存率高于对照组(P<0.05)。结论同步放化疗治疗中晚期宫颈癌患者疗效显著、安全性高,可提高患者5年内的生存率,值得推广应用。

Objective To explore the clinical effect of concurrent chemoradiotherapy in the treatment of advanced cervical cancer. Methods A total of 80 patients with advanced cervical cancer in our hospital from November 2016 to May2018 were randomly divided into control group and experimental group, with 40 cases in each group. The control group was treated with pure radiation, and the experimental group was treated with cisplatin combined with fluorouracil concurrent chemoradiotherapy. The treatment effects were compared between the two group. Results The effective rate of treatment in the experimental group was significantly higher than that in the control group, and the gastrointestinal toxic and side effect was lighter than that of the control group（P〈0.05）. After treatment, the levels of CD3^＋and CD4^＋, CD4^＋/CD8^＋in both groups significantly decreased（P〈0.05）, but there were no significant differences between the two groups（P〈0.05）. The survival rate within 5 year in the experimental group was higher than that in the control group（P〈0.05）. Conclusion Cisplatin combined with fluorouracil concurrent chemoradiotherapy in the treatment of advanced cervical cancer patients has a significant effect and high safety, and it can improve the survival rate of patients within 5 years, it is worthy of popularizing and application in clinic.