术前血清CEA、CA19-9、NLR及PLR水平的检测对胃癌术后复发转移率及预后的影响

Effect of preoperative serum CEA, CA19-9 levels, NLR and PLR detection on postoperative recurrence and metastasis rate and prognosis of gastric cancer

目的探讨术前血清CEA、CA19-9、NLR及PLR检测对胃癌术后复发转移率及预后的影响。方法选择在我院接受手术治疗的113例胃癌患者进行研究,全部患者于术前行血清CEA、CA19-9、NLR及PLR水平检测。随访1年,观察患者复发转移情况,分析CEA、CA19-9、NLR及PLR与病理指标及预后的关系。结果不同T分期、TMN分期、淋巴结有无转移、脉管浸润与CEA阳性、CA19-9阳性、高NLR和PLR水平之间均存在显著差异(P<0.05),CEA、CA19-9阳性患者复发转移率均高于阴性患者(P<0.05);高NLR、PLR患者复发转移率显著高于低NLR、PLR患者(P<0.05)。CEA、CA19-9阳性、阴性患者在不同NLR、PLR水平间数据差异显著(P<0.05)。结论术前血清CEA、CA19-9、NLR、PLR水平检测可预测胃癌术后复发转移情况,对患者预后状况具有指导意义,值得在临床上推广。

Objective To investigate the effect of preoperative serum CEA, CA19-9 levels, NLR and PLR detection on postoperative recurrence and metastasis rate and prognosis in gastric cancer. Methods A total of 113 patients with gastric cancer who underwent surgery in our hospital were selected. The preoperative serum CEA, CA19-9, NLR and PLR levels in all patients were determined. The patients were followed up for one year to observe the recurrence and metastasis of the patients, and the relationship between CEA, CA19-9, NLR and PLR and pathological indexes and prognosis were analyzed.Results There were significant differences between different T stages, different TMN lymph nodes, wether lymph node metastases, vessel invasive and positive CEA and CA19-9, high levels of NLR and PLR（P 0.05）, the recurrence and metastasis rate of CEA and CA19-9 positive patients were higher than those in negative patients（P〈0.05）. The recurrence and metastasis rates of patients with high NLR and PLR were significantly higher than those of patients with low NLR and PLR（P〈0.05）. The positive and negative CEA and CA19-9 patients showed significant difference between different NLR and PLR levels（P〈0.05）. Conclusion The detection of preoperative serum CEA, CA19-9, NLR and PLR levels can predict the postoperative recurrence and metastasis and prognosis of gastric cancer, it is of guiding significance to the prognosis of patients and worthy of promotion in clinic.