清胰合剂预防ERCP术后胰腺炎的临床疗效

Clinical effect of Qingyi mixture on preventing pancreatitis after ERCP

目的探讨清胰合剂预防内窥镜逆行胰胆管造影术(ERCP)术后胰腺炎的临床疗效。方法选取2017年2月至2018年2月于我院行ERCP的200例患者为研究对象,采用随机数表法将其分为对照组与观察组,各100例。对照组采用ERCP术治疗,观察组在对照组基础上采用清胰合剂治疗,比较两组患者的临床疗效。结果术前2 h,两组AMS、CRP、IL-10水平比较,无显著差异(P>0.05)。术后24 h,观察组的AMS、CRP及IL-10水平均显著低于对照组(P<0.05);观察组腹痛和腹胀消失时间、肠鸣音和自主排便恢复时间均明显短于对照组(P<0.05);观察组胰腺炎、高淀粉酶血症发生率(4.00%,8.00%)明显低于对照组的(24.00%,32.00%,P<0.05)。结论清胰合剂能明显预防ERPC术后胰腺炎的发生,减少患者炎症反应,疗效显著。

Objective To investigate the clinical effect of Qingyi mixture on preventing pancreatitis after endoscopic retrograde cholangiopancreatography（ERCP）. Methods From February 2017 to February 2018, a total of 200 patients undergoing ERCP in our hospital were selected as study objects. They were divided into control group and observation group by random number table method, with 100 cases in each group. The control group was treated with ERCP, and the observation group was treated with Qingyi mixture on the basis of the control group. The clinical effects were compared between the two groups. Results There were no significant differences in the levels of AMS, CRP, IL-10 between the two groups at 2 hours before operation（P〈0.05）. At 24 hours after operation, the levels of AMS, CRP and IL-10 in the observation group were significantly lower than those in the control group（P〈0.05）. The disappearance time of abdominal pain and distention, the recovery time of bowel sound and spontaneous defecation in the observation group were significantly shorter than those in the control group（P〈0.05）. The incidences of pancreatitis and hyperamylasemia in the observation group（4.00%, 8.00%） were significantly lower than those in the control group（24.00%, 32.00%, P〈0.05）.Conclusion Qingyi mixture can obviously prevent the occurrence of pancreatitis after ERPC, reduce the inflammatory reaction of patients, and the curative effect is remarkable.