小剂量阿司匹林与硫酸镁联用治疗妊娠期高血压疾病的临床疗效

Clinical efficacy of low-dose aspirin combined with magnesium sulfate in the treatment of hypertensive disorder complicating pregnancy

目的探讨小剂量阿司匹林与硫酸镁联用治疗妊娠期高血压疾病的疗效及对血压水平的影响。方法随机选择我院2016年6月至2018年6月收治的妊娠高血压疾病患者96例作为研究对象,采用随机数字表法将其分为对照组和观察组,每组48例。对照组给予硫酸镁进行治疗,观察组在此基础上给予患者小剂量阿司匹林进行治疗。对比两组患者的临床疗效、各临床指标的变化情况及不良反应发生情况。结果观察组患者的治疗总有效率显著高于对照组,差异具有统计学意义(P<0.05)。治疗后,两组患者的收缩压、舒张压水平及RI均降低,且观察组明显低于对照组,差异具有统计学意义(P<0.05)。观察组患者的全血黏度、尿素氮、尿酸和尿蛋白水平均显著低于对照组,差异具有统计学意义(P<0.05)。观察组患者的不良反应总发生率明显低于对照组,差异具有统计学意义(P<0.05)。结论在妊娠高血压疾病患者的治疗中,小剂量阿司匹林和硫酸镁联合应用疗效更佳,对临床各项指标改善显著,且安全性较高,推广价值较高。

Objective To investigate the efficiency of low-dose aspir in combined with magnesium sulfate on hypertensive disorder complicating pregnancy and the effect on blood pressure. Methods Ninety-six patients with hypertensive disorder complicating pregnancy admitted in our hospital from June 2016 in June 2018 were selected as the study objects. And the patients were divided into control group and observation group according to random number table method, with 48 cases in each group. The control group was treated with magnesium sulfate, while the observation group was treated with low-dose aspirin on the basis of this. The clinical efficacy, the changes of clinical indicators and occurrence of adverse reactions were compared between the two groups. Results The total effective rate of treatment in the observation group was significantly higher than that in the control group, and the difference was statistically significant（P〈0.05）. After treatment, the levels of systolic blood pressure and diastolic blood pressure, arterial resistance index（RI）decreased in both groups, and those of the observation group were significantly lower than the control group, and the differences were statistically significant（P〈0.05）. The levels of whole blood viscosity, urea nitrogen, uric acid and urine protein in the observation group were significantly lower than those in the control group, and the differences were statistically significant（P〈0.05）. The total incidence of adverse reactions in the observation group was significantly lower than that in the control group, and the difference was statistically significant（P〈0.05）. Conclusion In the treatment of patients with hypertensive disorder complicating pregnancy, the combination of low-dose aspirin and magnesium sulfate is effective, and the clinical indicators improve significantly. It has high safety and popularization value.