超声联合炎症因子检查对多囊卵巢综合征的临床诊断价值

Clinical diagnostic value of ultrasound combined with inflammatory factor test in polycystic ovary syndrome

目的探讨超声联合炎症因子检查对多囊卵巢综合征(PCOS)的临床诊断价值。方法选择2016年1月至2017年10月于我院接受超声检查的PCOS患者64例为观察组,选择同期体检的60例健康妇女为对照组。检测两组血清hs-CRP、IL-6与TNF-α水平;比较月经周期前不同时期子宫内膜厚度和卵巢血流动力学指标;观察促排卵成功、失败、妊娠成功及妊娠失败患者的卵巢血流动力学指标及子宫内膜厚度变化情况。结果观察组患者的hs-CRP、IL-6与TNF-α水平均高于对照组(P<0.05)。观察组患者月经周期前不同时期的子宫内膜厚度、左、右侧卵巢动脉阻力指数比较,差异均无统计学意义(P>0.05)。促排卵成功患者注射HCG当天及黄体酮中期子宫内膜厚度均大于促排卵失败患者,卵巢动脉阻力指数均小于促排卵失败患者(P<0.05)。妊娠成功患者的子宫内膜厚度大于妊娠失败患者(P<0.05)。不同妊娠情况患者的卵巢动脉阻力指数比较,差异均无统计学意义(P>0.05)。结论 PCOS患者体内炎症因子水平升高;超声检查有助于了解PCOS患者子宫内膜厚度及卵巢血流情况,其结合炎症因子水平检查可显著提高PCOS检出率。

Objective To investigate the clinical diagnostic value of ultrasound combined with inflammatory factor test in patients with polycystic ovary syndrome（PCOS）. Methods Sixty-four patients with PCOS who underwent ultrasound examination from January 2016 to October 2017 were enrolled as observation group. Sixty healthy women with physical examination at the same period were selected as control group. The levels of serum hs-CRP, IL-6 and TNF-α in the two groups were measured. The endometrial thickness and ovarian hemodynamics indexes were compared at different periods before menstrual cycle; the ovarian hemodynamics indexes and endometrial thickness of patients with successful ovulation induction, failed ovulation induction, pregnancy and pregnancy failure were observed. Results The levels of hs-CRP, IL-6 and TNF-α in the observation group were higher than those in the control group（P〈0.05）. There were no significant differences in endometrial thickness, left and right ovarian artery resistance indexes in patients at different periods before menstrual cycle（P〉0.05）. In patients with successful ovulation induction, the endometrial thickness at the day of HCG injection and medium term of progesterone were higher than those of patients with failed ovulation induction, and the ovarian artery resistance indexes were lower than those of patients with failed ovulation induction（P 〈0.05）. The endometrial thickness of patients with pregnancy was higher than that of patients with pregnancy failure（P〈0.05）. There was no significant difference in ovarian artery resistance indexe between patients with different pregnancy outcome（P 〉0.05）. Conclusion The levels of inflammatory factors increased in patients with PCOS, ultrasonography can help to understand the endometrial thickness and ovarian blood flow, which combined with inflammatory factor test can significantly improve the detection rate of PCOS.