干扰素、白细胞介素2联合沙利度胺治疗急性髓系白血病微小残留病阳性二例效果观察

Efficacy observation of interferon, interleukin-2 and thalidomide for treatment of two acute myeloidleukemia patients with minimal residual disease-positive

目的探讨干扰素、白细胞介素2联合沙利度胺（＂干白沙＂方案）治疗急性髓系白血病（AML）患者微小残留病（MRD）阳性的效果。方法对河南省肿瘤医院收治的2例完成巩固治疗后仍MRD阳性的AML患者给予＂干白沙＂方案，检测骨髓抽吸液MRD转归情况。结果2例患者在经过＂干白沙＂方案治疗后均达到MRD阴性。结论＂干白沙＂方案维持治疗可使巩固治疗后MRD阳性的AML患者达到MRD转阴。

Objective To explore the effectiveness of interferon, interleukin-2 and thalidomide （IIT regimen） for treatment of acute myeloid leukemia （AML） patients with minimal residual disease （MRD）- positive. Methods Two AML patients in Henan Tumor Hospital who were still MRD-positive after consolidation therapy received liT regimen, and the bone marrow aspirate was also detected. Results MRD of the two patients turned negative after IIT regimen. Conclusion Maintenance therapy with liT regimen in AML patients can turn MRD-positive to be negative after consolidation therapy.