结外NK／T细胞淋巴瘤分子机制研究进展

Progress of molecular pathogenesis of extranodal natural killer/T-cell lymphoma

结外NK/T细胞淋巴瘤（ENKTCL）是一种高度侵袭性的非霍奇金淋巴瘤（NHL），死亡率高。ENKTCL主要发生在亚洲、拉丁美洲等地区，中国、日本、韩国是该肿瘤的高发国家。EB病毒（EBV）感染与ENKTCL的发病密切相关，但导致其发病的具体分子机制尚不清楚。我国是ENKTCL的高发国家，有着丰富的病例资源，我国学者在探索ENKTCL的发病机制、治疗方法等方面做出了重要贡献，文章就近年来ENKTCL分子机制研究进展进行综述。

Extranodal nature killer/T cell lymphoma （ENKTCL） is a highly aggressive non-Hodgkin lymphoma （NHL） with a high mortality. ENKTCL is epidemic in Asia and Latin America, especially in China, Japan and South Korea. EBV has been proved to be associated closely with ENKTCL; however, specific molecular mechanism which can explain how the neoplasm develops is still unclear. Chinese population seems to be more susceptible to this lymphoma and Chinese scientists have made great contributions to thepathogenesis and the treatments of ENKTCL. This review mainly introduces the recent progress of molecular pathogenesis of ENKTCL.